Myelin-associated changes in mouse brain following irradiation.

  title={Myelin-associated changes in mouse brain following irradiation.},
  author={Chi-Shiun Chiang and William H McBride and Hubert Rodney Withers},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  volume={27 3},
  • C. ChiangW. McBrideH. Withers
  • Published 1 June 1993
  • Medicine, Biology
  • Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Changes in myelin basic protein and demyelination in the rat brain within 3 months of single 2-, 10-, or 30-Gy whole-brain radiation treatments.

The authors' results suggest that the early radiation-induced MBP changes between 1 and 3 months after single treatments of 10 and 30 Gy of radiation to the whole brain are indicative of permanent injury shown as demyelination of irradiated brain tissue.

Histological and elemental changes in the rat brain after local irradiation with carbon ion beams.

A histological examination showed that Necrotic tissue damage, hemorrhage in the thalamus, and vasodilatations around the necrotic region were induced at 8 weeks after 100 Gy irradiation, indicating an advantage of charged carbon particles for irradiating restricted brain regions.

Changes in oligodendrocytes and myelin gene expression after radiation in the rodent spinal cord.

Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus

The findings indicate that despite the differences in severity between the doses they both demonstrated an effect on cell proliferation and growth retardation, important factors in pediatric CRT.

Radiation-induced astrocytic and microglial responses in mouse brain.

Radiation-induced astrocytic and microglial responses in mouse brain

Levels of glial fibrillary acidic protein (GFAP), which is a marker for astrocytes, were measured by ELISA in irradiated brains taken at varying time points after irradiation and there was an increase in the number and the intensity of microglial cell staining for Mac I antigen.

Delayed molecular responses to brain irradiation.

The data suggest that TNF-alpha may be involved in late brain responses to irradiation and could contribute to clinical symptoms after higher doses.

Biological Principles of Radiotherapy in the Central Nervous System

Responses of the central nervous system (CNS) to irradiation may be broadly classified as acute, subacute and late, and occur in a similar manner for a conventional course of treatment or single-dose

Irradiation After Surgically Induced Brain Injury in the Rat: Timing in Relation to Severity of Radiation Damage

The data from this rat model suggest that, in humans, starting radiotherapy early (1–2 weeks) after debulking of a brain tumor may result in significantly higher levels of tissue damage than if the radiation is started 3 weeks or more postoperatively.

Utilizing the Faxitron MultiRad 225 X-ray irradiation system for the construction of mouse chronic whole brain radiation model.

This mouse WBR model using the Faxitron MultiRad 225 irradiation system with a single dose of 30 Gy is feasible to simulate the RBI-related chronic pathophysiological changes.



Alteration in myelin-associated proteins following spinal cord irradiation in guinea pigs.

Radiation dose response of normal brain.

  • J. FikeC. Cann R. Davis
  • Medicine, Physics
    International journal of radiation oncology, biology, physics
  • 1988

The nature of latent cerebral irradiation damage and its modification by hypertension.

The hypothesis is put forward that with low exposures of X rays radiation death is due to sudden vascular damage while with high values of exposure (3,000–4,000 R) death isdue to white matter necrosis which follows glial depletion and subependymal stem cell damage respectively.

Radiation sensitivity of glial cells in primary culture

Therapeutic irradiation and brain injury.

The turnover of myelin proteins in adult rat brain.

The turnover of proteins of myelin of brain was followed after an intracerebral injections of [1-14C] leucine into adult rats and compared with the turnover of proteins of total brain homogenate,

The relationship between fractionation and total dose for X ray induced brain damage.

Radiation‐induced dementia in patients cured of brain metastases

It is believed that these fractionation schedules, several of which are used commonly, predispose to delayed neurologic toxicity, and that more protracted schedules should be employed for the safe and efficacious treatment of good-risk patients with brain metastases.