Myelin-Specific Cd8 T Cells in the Pathogenesis of Experimental Allergic Encephalitis and Multiple Sclerosis

@article{Steinman2001MyelinSpecificCT,
  title={Myelin-Specific Cd8 T Cells in the Pathogenesis of Experimental Allergic Encephalitis and Multiple Sclerosis},
  author={Lawrence Steinman},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={194},
  pages={f27 - f30}
}
Experimental autoimmune encephalomyelitis (EAE) serves as the prototypic model for T cell–mediated autoim-munity. EAE has striking similarities with the human disease acute disseminated encephalomyelitis, a complication seen with vaccination and after certain viral infections. EAE has been used as a model to help understand the pathogenesis of multiple sclerosis (MS) and to help identify potential therapeutic candidates for this disease (Table I), Until now, research has focused nearly… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Myelin basic protein T helper 2 cells cause experimental autoimmune encephalomyelitis in immunodeficient mice rather than protect them from disease

  • J. J. Lafaille, F. V. Keere, +4 authors S. Tonegawa
  • J. Exp. Med
  • 1997

Polman CH treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial

  • B. W. van Oosten, M. Lai, +8 authors H.J
  • Adèr
  • 1997

Similar Papers

Loading similar papers…