Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

@article{Snaidero2014MyelinMW,
  title={Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue},
  author={Nicolas Snaidero and Wiebke M{\"o}bius and Tim Czopka and Liesbeth H. P. Hekking and Cliff Mathisen and Dick Verkleij and Sandra Goebbels and J. Chris Edgar and Doron Merkler and David A Lyons and Klaus-Armin Nave and Mikael Simons},
  journal={Cell},
  year={2014},
  volume={156},
  pages={277-290}
}
Central nervous system myelin is a multilayered membrane sheath generated by oligodendrocytes for rapid impulse propagation. However, the underlying mechanisms of myelin wrapping have remained unclear. Using an integrative approach of live imaging, electron microscopy, and genetics, we show that new myelin membranes are incorporated adjacent to the axon at the innermost tongue. Simultaneously, newly formed layers extend laterally, ultimately leading to the formation of a set of closely apposed… CONTINUE READING
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