Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

@article{Emery2009MyelinGR,
  title={Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination},
  author={Ben Emery and Dritan Agalliu and John D. Cahoy and Trent A Watkins and Jason C. Dugas and Sara B. Mulinyawe and Adilijan Ibrahim and Keith L Ligon and David H Rowitch and Ben A Barres},
  journal={Cell},
  year={2009},
  volume={138},
  pages={172-185}
}
The transcriptional control of CNS myelin gene expression is poorly understood. Here we identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination. Within the CNS, MRF is specifically expressed by postmitotic oligodendrocytes. MRF is a nuclear protein containing an evolutionarily conserved DNA binding domain homologous to a yeast transcription factor. Knockdown of MRF in oligodendrocytes by RNA interference… CONTINUE READING
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