Mydriasis model in rats as a simple system to evaluate a2-adrenergic activity of the imidazol(in)e compounds


Imidazol(in)e compounds show the diversity of pharmacological effects including mydriasis, hypotension, sedation, bradycardia and hypothermia. At first it was postulated that these effects are mediated via a2-adrenoceptors exclusively. Clonidine is well known as a model agent to produce pupillary dilation in rats. However, it became obvious later that… (More)


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