• Corpus ID: 39095351

Mycotoxin- A Target for Anticancer Drug Development

  title={Mycotoxin- A Target for Anticancer Drug Development},
  author={Sagar Naskar and Amitava Ghosh and Partha Mahata},
The aim of this present article is to underscore the recent evidence linking anticancer activity and free radical scavenging activity of mycotoxins and its significance in the development of newer anticancer drugs. Although acute exposure to a massive amount of mycotoxin is rare but long-term exposure/consumption of food with low levels of lipophilic mycotoxin remains problematic. The aneuploidogenic and clastogenic potentials of the mycotoxins citrinin and patulin were studied in human cells… 
Induction of G2/M cell cycle arrest and phosphorylated-extracellular signal-regulated protein kinase 1 and 2-induced caspase 3/7-independent apoptosis in HT-29 cells by the combination of fraction S1 and citrinin from Penicillium strain H9318
Citrinin H9318 alone did not reduce activity of caspase-3/7 significantly in the apoptosis of HT-29 cells, and the combination treatment of fraction S1 and citrininH9318 contributed to apoptosis via up-regulation of p-ERK1/2 with reduced activity ofcaspases 3/7.


Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo
It is confirmed that gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with pronounced antitumor activity and favorable toxicity profile against breast cancer in vitro and in vivo.
Apoptosis induction by 4beta-acetoxyscirpendiol from Paecilomyces tenuipes in human leukaemia cell lines.
It is suggested that acetoxyscirpendiol exerts its cytotoxic activity by inducing apoptosis in leukaemia cell lines in vitro.
The thioredoxin system: a key target in tumour and endothelial cells.
The current report reviews the thioredoxin system as an anticancer drug target and focuses upon two recent compounds, PMX464 and PX12, which reportedly inhibit this important pathway.
Mechanisms of Mycotoxin-induced Dermal Toxicity and Tumorigenesis Through Oxidative Stress-related Pathways
The molecular mechanisms of dermal toxicity and tumorigenesis induced in rodent models by these mycotoxins are reviewed from the viewpoint of oxidative stress-mediated pathways.
Reactive oxygen species: an Achilles’ heel of melanoma?
A recent randomized Phase II trial with elesclomol, an agent that generates ROS, in combination with paclitaxel led to improved patient survival, suggesting that this may be a viable approach to advance the treatment of melanoma.
The antioxidant function of the p53 tumor suppressor
It is shown that p53 protects the genome from oxidation by reactive oxygen species (ROS), a major cause of DNA damage and genetic instability, and relatively low levels of p53 are sufficient for upregulation of several genes with antioxidant products, which is associated with a decrease in intracellular ROS.
Mycotoxins, mycotoxicoses, mycotoxicology andMycopathologia
The eclectic nature of the discipline and the international scope of the problem has attracted scientists from many different backgrounds, and the publishers and editors of Mycopathologia intend for this journal to become a major forum for mycotoxin research.
Protective effect of tenuazonic acid against dimethyl benz(a)antracene-induced skin carcinogenesis in mice.
Results indicated that prior application of TA significantly delayed the onset of tumorigenesis and also reduced the cumulative number of tumors per tumor-bearing animals.
Reactive Oxygen Species: A Breath of Life or Death?
Recent work in ROS-mediated signaling in cancer cells and its potential as a target for developmental therapeutics is covered.
Thioredoxin signaling as a target for cancer therapy.