• Corpus ID: 39095351

Mycotoxin- A Target for Anticancer Drug Development

@inproceedings{Naskar2015MycotoxinAT,
  title={Mycotoxin- A Target for Anticancer Drug Development},
  author={Sagar Naskar and Amitava Ghosh and Partha Mahata},
  year={2015}
}
The aim of this present article is to underscore the recent evidence linking anticancer activity and free radical scavenging activity of mycotoxins and its significance in the development of newer anticancer drugs. Although acute exposure to a massive amount of mycotoxin is rare but long-term exposure/consumption of food with low levels of lipophilic mycotoxin remains problematic. The aneuploidogenic and clastogenic potentials of the mycotoxins citrinin and patulin were studied in human cells… 
Induction of G2/M cell cycle arrest and phosphorylated-extracellular signal-regulated protein kinase 1 and 2-induced caspase 3/7-independent apoptosis in HT-29 cells by the combination of fraction S1 and citrinin from Penicillium strain H9318
TLDR
Citrinin H9318 alone did not reduce activity of caspase-3/7 significantly in the apoptosis of HT-29 cells, and the combination treatment of fraction S1 and citrininH9318 contributed to apoptosis via up-regulation of p-ERK1/2 with reduced activity ofcaspases 3/7.

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