Mycothiol disulfide reductase: a continuous assay for slow time-dependent inhibitors.

Abstract

Mycothiol (MSH) is the principal low-molecular-weight thiol, unique to mycobacteria and other actinomycetes, that performs a role analogous to glutathione found in other organisms. MSH plays a key role in oxidative stress management and is oxidized to the dimeric mycothiol disulfide (MSSM) in the process. NADPH-dependent mycothiol disulfide reductase (Mtr… (More)
DOI: 10.1016/j.ab.2009.02.015

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