Mycosis fungoides: Review of Epidemiological Observations

  title={Mycosis fungoides: Review of Epidemiological Observations},
  author={Maria M. Morales Suarez-Varela and A. Llopis gonz{\'a}lez and A Marquina Vila and Jonathan Bell},
  pages={21 - 28}
Background: Mycosis fungoides (MF) is a chronic cutaneous T-cell lymphoma characterized by small cells with cerebriform nuclei that usually express a mature peripheral T-helper cell (CD4+) immunophenotype. Its evolution is typically quite slow, with years between the first manifestations and development of advanced stages of disease. Objective: The purpose of the present paper is to contribute to the material about MF already present in the literature. The review articles that have appeared to… 

Figures and Tables from this paper

Mycosis Fungoides: An Updated Review of Clinicopathologic Variants

It is important for dermatologists and dermatopathologists to be knowledgeable of the widely varied clinical, histological, and immunohistochemical presentations of MF to arrive at a prompt and accurate diagnosis and initiate appropriate treatment.

Mycosis fungoides: A report of two cases

Mycosis fungoides is one of the non-Hodgkin lymphoma that is presented with cutaneous lesions and it has an indolent clinical course, however, the disease was under-diagnosed in the authors' environments.

Mycosis Fungoides: A Clinicopathological Study of 60 Cases from a Tertiary Care Center

Clinical information and histological features are equally important in the accurate diagnosis of MF, and Papillary dermal fibrosis is a useful diagnostic clue.

Modern concepts of the mycosis fungoides pathogenesis

The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date, and potential directions in studying molecular-biological predictors of malignant lymphoproliferative diseases development are highlighted.

Mycosis fungoides mimicking neurofibromatosus and aspergillosis: reports of two unusual presentation and literature review

Two cases that presented in unusual form are reported to highlight the need to subject suspicious cutaneous lesion for histo-pathological studies and its risk factors are not well elucidated worldwide.

Unusual involvement in mycosis fungoides: Duodenal papilla.

This case report proves the value of the endoscopic studies in patients with lymphoproliferative disorders, because of the impact in the diagnosis and prognosis.

Radiotherapy Approach in the Treatment of Mycosis Fungoides: Principles and Recommendations

Radiotherapy is indicated for patients suffering from mycosis fungoides in all stages especially when the disease has affected more than 50% of the body surface.

A new molecular paradigm in mycosis fungoides and Sézary syndrome.

The recent findings elucidating the genomic landscape of MF and SS are discussed, the pathways targeted by mutational alterations are discussed and a model for understanding the pathogenesis of these diseases is proposed.



Mycosis fungoides and Sezary syndrome.

The diagnosis of MF rests on the clinical presentation as well as the histopathologic findings of an epidermotropic lymphoma with light microscopy showing a dermal infiltrate of lymphocytes with hyperconvoluted cerebriform nuclei and Pautrier's microabscesses.

Mycosis fungoides in Patients under 20 Years of Age: Report of 7 Cases, Review of the Literature and Study of the Clinical Course

No statistically significant differences were found in the disease course between early- and adult-onset MF, and the predominant phenotype was CD3+ CD4+CD7–CD8–.

Mycosis fungoides: The pathology of extracutaneous involvement

A survey of the autopsy material of 45 clinically and histologically typical cases of mycosis fungoides (M.F.) revealed extracutaneous involvement in 32, or 71%. The lymph nodes showed diagnosable

Mycosis fungoides and the Sézary syndrome: a review of pathogenesis, diagnosis, and therapy.

  • T. KuzelH. RoenigkS. Rosen
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1991
The development of advanced laboratory techniques, such as molecular genetics and cell-surface phenotyping, has greatly enhanced the authors' understanding of mycosis fungoides and the Sézary syndrome and may lead to identification of responsible etiologic factors.

Mycosis fungoides: Clinicopathologic relationships, survival, and therapy in 59 patients with observations on occupation as a new prognostic factor

Among 30 different types of treatment employed during the course of this study, highdose electron beam was superior to all other physical and chemotherapeutic modalities and the concept that occupational factors may be implicated in the etiology of mycosis fungoides provides a new dimension to previous pathogenic hypotheses.

Cutaneous T-cell lymphomas: the Sézary syndrome, mycosis fungoides, and related disorders.

It is suggested that these lymphoproliferative disorders be grouped together as "cutaneous T-cell lymphomas", because the anergy noted in patients of this group with leukemia probably is related to both decreased percentages of normal T cells and presence in the serum of macrophage migration inhibitory activity.

Cutaneous lymphomas consist of a spectrum of nosologically different entities including mycosis fungoides and small plaque parapsoriasis.

It is argued that small plaque (digitate) parapsoriasis (SPP) must be mycosis fungoides (MF), while Burg and Dummer state that SPP is an "abortive" cutaneous T-cell lymphoma (CTCL) kept in a biologically silent stage, but it is not MF.

Mycosis fungoides—a disease of antigen persistence

The function of B‐ and T‐lymphocytes in nineteen patients with classical Alibert's mycosis fungoides (MF) was studied. In general there was no evidence of immune depression, not even in those with