Mycoplasmas regulate the expression of heat-shock protein genes through CIRCE-HrcA interactions.

@article{Chang2008MycoplasmasRT,
  title={Mycoplasmas regulate the expression of heat-shock protein genes through CIRCE-HrcA interactions.},
  author={Li-Jen Chang and Wei-Hsiuan Chen and F. Chris Minion and David Shiuan},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={367 1},
  pages={213-8}
}
Mycoplasmas in general are rarely exposed to severe environmental changes except during its colonization and infection processes. Genomic analysis indicates that Mycoplasma hyopneumoniae possesses the genes of a single sigma factor and the HrcA repressor of negative regulation of the heat-shock response. A perfect inverted repeat sequence (5'-CTGGCACTT-N(9)-AAGTGCCAA-3') upstream of the DnaK gene has also been identified. In the present study, we demonstrate the functionality of HrcA-CIRCE… CONTINUE READING