Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells.

Abstract

Evidence of Mycoplasma hyorhinis infection in human gastric cancer tissues has been found in previous work. In this study, we demonstrate that the expression of p37, a membrane lipoprotein of M. hyorhinis, in mammalian cells induces antisenescence, enhances clonogenicity in soft agar, and co-operates with human epidermal growth factor receptor-related 2 to inhibit cell adhesion. Conversely, truncated p37 protein, with the first 28 amino acids deleted from its N terminal, promotes cell senescence. Taken together, our findings suggest that p37 promotes malignant changes in mammalian cells. With the identification of this molecular component, which is responsible for mycoplasma malignancy-promoting activity, it is possible that a better understanding of the relationship between M. hyorhinis infection and human gastric cancers will lead to novel diagnostics and therapeutics.

Cite this paper

@article{Liu2007MycoplasmalMP, title={Mycoplasmal membrane protein p37 promotes malignant changes in mammalian cells.}, author={Wenbin Liu and Tingting Ren and Beihai Jiang and Manman Gong and Cheng-chao Shou}, journal={Canadian journal of microbiology}, year={2007}, volume={53 2}, pages={270-6} }