Mycoplasma fermentans—Induced Inflammatory Response of Astrocytes: Selective Modulation by Aminoguanidine, Thalidomide, Pentoxifylline and IL-10

@article{Gallily2004MycoplasmaFI,
  title={Mycoplasma fermentans—Induced Inflammatory Response of Astrocytes: Selective Modulation by Aminoguanidine, Thalidomide, Pentoxifylline and IL-10},
  author={R. Gallily and M. Kipper-Galperin and T. Brenner},
  journal={Inflammation},
  year={2004},
  volume={23},
  pages={495-505}
}
  • R. Gallily, M. Kipper-Galperin, T. Brenner
  • Published 2004
  • Biology, Medicine
  • Inflammation
  • Exposure of primary rat glial cells, mostly astrocytes, to heat-inactivated Mycoplasma fermentans triggers the production of tumor necrosis factor α (TNFα) nitric oxide (NO) and prostaglandin E2 (PGE2). To attenuate the production of these proinflammatory mediators, four agents: aminoguanidine, pentoxifylline, thalidomide and IL-10 were added to astrocyte cultures. Aminoguanidine (1 and 3 mM), an inhibitor of inducible nitric oxide synthase (iNOS), suppressed the production of the three… CONTINUE READING
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