Mycophenolic acid mediated disruption of the intestinal epithelial tight junctions.

@article{Qasim2014MycophenolicAM,
  title={Mycophenolic acid mediated disruption of the intestinal epithelial tight junctions.},
  author={M Shehbaz Qasim and Hazir Rahman and Raees Ahmed and Michael Oellerich and Abdul R Asif},
  journal={Experimental cell research},
  year={2014},
  volume={322 2},
  pages={277-89}
}
Gastrointestinal toxicity is a common adverse effect of mycophenolic acid (MPA) treatment in organ transplant patients, through poorly understood mechanisms. Phosphorylation of myosin light chain 2 (MLC2) is associated with epithelial tight junction (TJ) modulation which leads to defective epithelial barrier function, and has been implicated in GI diseases. The aim of this study was to investigate whether MPA could induce epithelial barrier permeability via MLC2 regulation. Caco-2 monolayers… CONTINUE READING