Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines.

@article{Cohn1999MycophenolicAI,
  title={Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines.},
  author={Robert Greer Cohn and Anna Mirkovich and Beth E. Dunlap and Philip Burton and S H Chiu and Elsie M. Eugui and John P. Caulfield},
  journal={Transplantation},
  year={1999},
  volume={68 3},
  pages={
          411-8
        }
}
BACKGROUND Mycophenolic acid (MPA), a selective inhibitor of inosine monophosphate dehydrogenase, is the active agent of the immunosuppressive drug, mycophenolate mofetil (MMF). Previous studies have shown that MPA inhibits DNA synthesis in T and B lymphocytes by blocking de novo guanosine synthesis, and that MPA induces monocyte differentiation. MMF is being used for prevention of organ graft rejection and has also shown efficacy in rheumatoid arthritis trials. This study was designed to… CONTINUE READING

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