Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus.

@article{Patel2013MycophenolicAG,
  title={Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus.},
  author={Chirag G Patel and Ken Ogasawara and Fatemeh Akhlaghi},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2013},
  volume={43 3},
  pages={229-35}
}
1. The purpose of this study was to investigate the contribution of MRP2 to the efflux of mycophenolic acid (MPA), and its phenyl glucuronide (MPAG) and acyl glucuronide (AcMPAG) metabolites, using Madin-Darby canine kidney II cells stably transfected with human MRP2 gene (MDCKII/MRP2 cells). 2. Compared to parental MDCKII cells, MPAG was significantly translocated from basolateral (BL) to apical (AP) side in MDCKII/MRP2 cells, indicating MPAG is a substrate for MRP2. AcMPAG is highly… CONTINUE READING

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Spanish Pharmacogenetic Symphony Substudy Group

  • N Lloberas, J Torras, +7 authors JM Grinyó
  • 2011
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