Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties

@article{Carter1969MycophenolicAA,
  title={Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties},
  author={S. Carter and T. Franklin and D. F. Jones and B. Leonard and S. D. Mills and R. W. Turner and W. Turner},
  journal={Nature},
  year={1969},
  volume={223},
  pages={848-850}
}
MYCOPHENOLIC acid (UK patent applications 43131/66 and 43132/66) emerged as a potential anti-cancer compound during routine screening tests with mould filtrates for activity against mouse fibroblasts. Our aim was to detect substances having a more specific action than general lethality: substances which, for example, inhibit cell division or interfere with the mitotic mechanism. 

Topics from this paper

Carbamoyl mycophenolic acid ethylester, an oral antitumor agent.
The effect of mycophenolic acid on the cell cycle ofCandida albicans
Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target.
Antitumor agents II: nitrogen analogs of mycophenolic acid.
Anticancer fungal natural products: Mechanisms of action and biosynthesis.
GLC of mycophenolic acid and related compounds.
...
1
2
3
4
5
...

References

SHOWING 1-9 OF 9 REFERENCES
The inhibition of nucleic acid synthesis by mycophenolic acid.
Amino acid metabolism in mammalian cell cultures.
Mycophenolic acid: antiviral and antitumor properties.
The effect of mycophenolic acid on the growth of Staphylococcus aureus in heart broth.
  • E. Abraham
  • Chemistry, Medicine
  • The Biochemical journal
  • 1945