Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis.

@article{Dooley2011MycophenolateVA,
  title={Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis.},
  author={M. Dooley and D. Jayne and E. Ginzler and D. Isenberg and N. Olsen and D. Wofsy and F. Eitner and G. Appel and G. Contreras and L. Lisk and N. Solomons},
  journal={The New England journal of medicine},
  year={2011},
  volume={365 20},
  pages={
          1886-95
        }
}
  • M. Dooley, D. Jayne, +8 authors N. Solomons
  • Published 2011
  • Medicine
  • The New England journal of medicine
  • BACKGROUND Maintenance therapy, often with azathioprine or mycophenolate mofetil, is required to consolidate remission and prevent relapse after the initial control of lupus nephritis. METHODS We carried out a 36-month, randomized, double-blind, double-dummy, phase 3 study comparing oral mycophenolate mofetil (2 g per day) and oral azathioprine (2 mg per kilogram of body weight per day), plus placebo in each group, in patients who met response criteria during a 6-month induction trial. The… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Systemic Lupus Erythematosus (SLE) is a disease in which the immune system attacks the healthy cells and tissues, causing inflammation that can damage organs in the body. About 50… Expand
    ConditionsLupus Nephritis
    InterventionDrug
    INTERVENTIONAL CLINICAL TRIAL
    The purpose of this study is assess the long-term safety and tolerability of voclosporin compared with placebo for up to an additional 24 months following completion of treatment in… Expand
    ConditionsLupus Nephritis
    InterventionDrug
    INTERVENTIONAL CLINICAL TRIAL
    The purpose of this study is to assess the efficacy of voclosporin compared with placebo in achieving renal response after 52 weeks of therapy in subjects with active lupus nephritis… Expand
    ConditionsLupus Nephritis
    InterventionDrug

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 28 REFERENCES