Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure.

@article{RodriguezIturbe2001MycophenolateMP,
  title={Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure.},
  author={B. Rodriguez-Iturbe and H. Pons and Y. Quiroz and K. Gordon and J. Rincon and M. Ch{\'a}vez and G. Parra and J. Herrera-Acosta and D. G{\'o}mez-Garre and R. Largo and J. Egido and R. Johnson},
  journal={Kidney international},
  year={2001},
  volume={59 6},
  pages={
          2222-32
        }
}
BACKGROUND Interstitial mononuclear cell infiltration is a feature of experimental models of salt-sensitive hypertension (SSHTN). Since several products of these cells are capable of modifying local vascular reactivity and sodium reabsorption, we investigated whether mycophenolate mofetil (MMF), a drug known to inhibit infiltration and proliferation of immune cells, would modify the SSHTN induced by angiotensin II (Ang II) infusion. METHODS Sprague-Dawley rats received Ang II for two weeks… Expand
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