Mycophenolate mofetil pharmacokinetic monitoring in pediatric kidney transplant recipients.

  title={Mycophenolate mofetil pharmacokinetic monitoring in pediatric kidney transplant recipients.},
  author={Luciana Ghio and Mariano Ferraresso and Sara Maria Vigan{\`o} and Fabrizio Ginevri and Francesco Perfumo and B Gianoglio and Luisa Murer and Graziella Zacchello and Luca Dello Strologo and Massimo Cardillo and Silvia Tirelli and U. Valente and Alberto Edefonti},
  journal={Transplantation proceedings},
  volume={37 2},
This open-label, longitudinal, long-term study of de novo pediatric renal transplant recipients was designed to investigate the pharmacokinetics (PK) of mycophenolic acid (MPA) and its possible interaction with cyclosporine (CsA). Thirty-four children on an immunosuppressive regimen of CsA, prednisone, and mycophenolate mofetil (MMF, 300-400 mg/m2 twice daily) were investigated at 6, 30, 180, and 360 days after transplantation. Considerable interindividual variability in the areas under the… CONTINUE READING