Mycophenolate mofetil for induction and maintenance of remission in microscopic polyangiitis with mild to moderate renal involvement--a prospective, open-label pilot trial.

@article{Silva2010MycophenolateMF,
  title={Mycophenolate mofetil for induction and maintenance of remission in microscopic polyangiitis with mild to moderate renal involvement--a prospective, open-label pilot trial.},
  author={Francisco Mayron de Sousa e Silva and Ulrich Specks and Sanjay Kalra and Marie Hogan and Nelson Leung and Sanjeev Sethi and Fernando C Fervenza},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  year={2010},
  volume={5 3},
  pages={445-53}
}
BACKGROUND AND OBJECTIVES Microscopic polyangiitis (MPA) is a systemic small-vessel vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCA), often targeting myeloperoxidase (MPO). Cyclophosphamide (CYC) plus corticosteroids (CS) is considered standard therapy for patients with renal involvement, but treatment response is not satisfactory in all patients and CYC has well recognized toxicity. This prospective pilot trial explored whether mycophenolate mofetil (MMF) represents an… CONTINUE READING

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Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis

  • K De Groot, N Rasmussen, +6 authors DR Jayne
  • Clinical Journal of the American Society of…
  • 2010
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