Mycophenolate and sirolimus as calcineurin inhibitor-free immunosuppression improves renal function better than calcineurin inhibitor-reduction in late cardiac transplant recipients with chronic renal failure.

@article{Groetzner2009MycophenolateAS,
  title={Mycophenolate and sirolimus as calcineurin inhibitor-free immunosuppression improves renal function better than calcineurin inhibitor-reduction in late cardiac transplant recipients with chronic renal failure.},
  author={Jan Groetzner and Ingo Kaczmarek and Uwe Schulz and Emilia Stegemann and Kristina Kaiser and Thorsten Wittwer and Johannes Schirmer and Meinolf Voss and Justus Strauch and Thorsten Wahlers and Hae-Young Sohn and Florian Wagner and Gero Tenderich and H U Stempfle and Jochen M{\"u}ller-Ehmsen and Christof Schmid and Michael Vogeser and Karrl Christian Koch and Hermann C Reichenspurner and Sabine H. Daebritz and Bruno M. Meiser and B. W. Carney G. N. Cecil C. R. Evans H. J. Karwowski Reichart},
  journal={Transplantation},
  year={2009},
  volume={87 5},
  pages={726-33}
}
BACKGROUND Calcineurin-inhibitor-(CNI)-induced renal failure is one major cause of morbidity in cardiac transplantation (HTx). In this prospective, randomized, multicenter trial, the impact of immunosuppressive conversion toward CNI-free (mycophenolate mofetil [MMF] and sirolimus) or a CNI-reduced immunosuppressive regimen on renal function, efficacy, and safety was evaluated. METHODS Since 2004, 63 HTx-patients (0.5-18.4 years after HTx) with CNI-based immunosuppression and reduced… CONTINUE READING
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