Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis.

@article{Lemmer2015MycolicAA,
  title={Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis.},
  author={Y. Lemmer and L. Kalombo and R. Pietersen and Arwyn T Jones and B. Semete-Makokotlela and S. van Wyngaardt and B. Ramalapa and A. Stoltz and B. Baker and J. Verschoor and H. Swai and C. de Chastellier},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={211},
  pages={
          94-104
        }
}
The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations of current therapies, we have designed a new nanoformulation for use as an anti-TB drug delivery system. It consists of incorporating mycobacterial cell wall mycolic acids (MA) as targeting ligands into a drug-encapsulating Poly dl-lactic-co-glycolic acid… Expand
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