Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.

@article{Kremer2002MycolicAB,
  title={Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.},
  author={Laurent Kremer and Lynn G. Dover and S{\'e}verine Carr{\`e}re and Kesavan Madhavan Nampoothiri and Sarah Lesjean and Alistair K Brown and Patrick Joseph Brennan and David E. Minnikin and Camille Locht and Gurdyal S Besra},
  journal={The Biochemical journal},
  year={2002},
  volume={364 Pt 2},
  pages={
          423-30
        }
}
Mycolic acids consist of long-chain alpha-alkyl-beta-hydroxy fatty acids that are produced by successive rounds of elongation catalysed by a type II fatty acid synthase (FAS-II). A key feature in the elongation process is the condensation of a two-carbon unit from malonyl-acyl-carrier protein (ACP) to a growing acyl-ACP chain catalysed by a beta-ketoacyl-ACP synthase (Kas). In the present study, we provide evidence that kasA from Mycobacterium tuberculosis encodes an enzyme that elongates in… CONTINUE READING

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