Mycolactone subverts immunity by selectively blocking the Sec61 translocon

  title={Mycolactone subverts immunity by selectively blocking the Sec61 translocon},
  author={Ludivine Baron and Anja Onerva Paatero and Jean-David Morel and Francis Impens and Laure Guenin-Mac{\'e} and Sarah Saint-Auret and Nicolas K. Blanchard and Rabea Dillmann and Fatoumata Niang and Sandra Pellegrini and Jack Taunton and Ville O Paavilainen and Caroline Demangel},
  booktitle={The Journal of experimental medicine},
Mycolactone, an immunosuppressive macrolide released by the human pathogen Mycobacterium ulcerans, was previously shown to impair Sec61-dependent protein translocation, but the underlying molecular mechanism was not identified. In this study, we show that mycolactone directly targets the α subunit of the Sec61 translocon to block the production of secreted… CONTINUE READING

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