Mycobacterium ulcerans toxic macrolide, mycolactone modulates the host immune response and cellular location of M. ulcerans in vitro and in vivo.

@article{Adusumilli2005MycobacteriumUT,
  title={Mycobacterium ulcerans toxic macrolide, mycolactone modulates the host immune response and cellular location of M. ulcerans in vitro and in vivo.},
  author={Sarojini Adusumilli and Armand Mve-Obiang and Tim Sparer and Wayne M. Meyers and John Hayman and Pamela Long Claus Small},
  journal={Cellular microbiology},
  year={2005},
  volume={7 9},
  pages={1295-304}
}
Mycobacterium ulcerans produces an extracellular cutaneous infection (Buruli ulcer) characterized by immunosuppression. This is in stark contrast to all other pathogenic Mycobacteria species that cause intracellular, granulomatous infections. The unique mycobacterial pathology of M. ulcerans infection is attributed to a plasmid-encoded immunomodulatory macrolide toxin, mycolactone. In this article we explore the role of mycolactone in the virulence of M. ulcerans using mycolactone and… CONTINUE READING
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