Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance

@inproceedings{Phelan2016MycobacteriumTW,
  title={Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance},
  author={Jody Phelan and Francesc Coll and Ruth McNerney and David B. Ascher and Douglas Eduardo Valente Pires and Nick Furnham and Nele Coeck and Grant A Hill-Cawthorne and Mridul B. Nair and Kim Mallard and Andrew Ramsay and Susana G. Campino and Martin L. Hibberd and Arnab Pain and Leen Rigouts and Taane G. Clark},
  booktitle={BMC medicine},
  year={2016}
}
BACKGROUND Combating the spread of drug resistant tuberculosis is a global health priority. Whole genome association studies are being applied to identify genetic determinants of resistance to anti-tuberculosis drugs. Protein structure and interaction modelling are used to understand the functional effects of putative mutations and provide insight into the molecular mechanisms leading to resistance. METHODS To investigate the potential utility of these approaches, we analysed the genomes of… CONTINUE READING
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