Mycobacterium tuberculosis strains with the Beijing genotype demonstrate variability in virulence associated with transmission.

@article{Aguilar2010MycobacteriumTS,
  title={Mycobacterium tuberculosis strains with the Beijing genotype demonstrate variability in virulence associated with transmission.},
  author={Diana Aguilar and Madeleine Hanekom and Danielle Mata and Nicolaas Claudius Gey van Pittius and Paul D van Helden and Robin Mark Warren and Rogelio E Hern{\'a}ndez-Pando},
  journal={Tuberculosis},
  year={2010},
  volume={90 5},
  pages={319-25}
}
Phylogenetic analysis has shown that Beijing genotype strains can be grouped into at least 7 different sublineages. We aimed to test the hypothesis that the virulence of Beijing genotype strains differed among members of the different sublineages and that the level of virulence correlated with their ability to spread and cause disease. BALB/c mice were infected with Beijing strains representative of the different lineages and of different epidemiological characteristics (transmitted vs. non… CONTINUE READING