Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro.

@article{Hanekom2003MycobacteriumTI,
  title={Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro.},
  author={Willem Albert Hanekom and Megan Mendillo and Claudia Manca and Patrick A. J. Haslett and Mahveen Ruby Siddiqui and Clifton E Barry and Gilla Kaplan},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={188 2},
  pages={257-66}
}
To induce effector immunity, dendritic cells (DCs) must differentiate into fully mature cells. We show that, after human monocyte-derived DCs were infected with virulent Mycobacterium tuberculosis, up-regulation of cellular-surface maturation markers was minimal and reversible. In the presence of a potent stimulus for maturation (tumor necrosis factor [TNF]-alpha, interleukin [IL]-1beta, and prostaglandin E2 [PGE2]), M. tuberculosis inhibited phenotypic DC maturation. M. tuberculosis-infected… CONTINUE READING

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