Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo.

@article{Wolf2007MycobacteriumTI,
  title={Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo.},
  author={Andrea J. Wolf and Beth Linas and Giraldina J. Trevejo-Nu{\~n}ez and Eleanor Z Kincaid and Toshiki Tamura and Kiyoshi Takatsu and Joel D Ernst},
  journal={Journal of immunology},
  year={2007},
  volume={179 4},
  pages={2509-19}
}
Mycobacterium tuberculosis (Mtb) is thought to reside in macrophages, although infected dendritic cells (DCs) have been observed. Thus, although cellular associations have been made, global characterization of the cells harboring Mtb is lacking. We have performed temporal and quantitative characterization of the cells harboring Mtb following aerosol infection of mice by using GFP-expressing bacteria and flow cytometry. We discovered that Mtb infects phagocytic cells of diverse phenotypes, that… CONTINUE READING
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