Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.

@article{Schierloh2007MycobacteriumTG,
  title={Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.},
  author={Pablo Schierloh and Noem{\'i} Yokobori and Mercedes Alem{\'a}n and Ver{\'o}nica In{\'e}s Landoni and Laura J Geffner and Rosa Mar{\'i}a Musella and Jorge P Castagnino and Mat{\'i}as Baldini and Eduardo Abbate and Silvia de la Barrera and Mar{\'i}a Del Carmen Sasiain},
  journal={Infection and immunity},
  year={2007},
  volume={75 11},
  pages={5325-37}
}
Tuberculous pleurisy allows the study of human cells at the site of active Mycobacterium tuberculosis infection. In this study, we found that among pleural fluid (PF) lymphocytes, natural killer (NK) cells are a major source of early gamma interferon (IFN-gamma) upon M. tuberculosis stimulation, leading us to investigate the mechanisms and molecules involved in this process. We show that the whole bacterium is the best inducer of IFN-gamma, although a high-molecular-weight fraction of culture… CONTINUE READING

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