Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression.

@article{Scott2002MycobacteriumTI,
  title={Mycobacterium tuberculosis in chemokine receptor 2-deficient mice: influence of dose on disease progression.},
  author={Holly M Scott and JoAnne L. Flynn},
  journal={Infection and immunity},
  year={2002},
  volume={70 11},
  pages={5946-54}
}
Within a Mycobacterium tuberculosis-induced granuloma, lymphocytes and macrophages work together to control bacterial growth and limit the spread of infection. Chemokines and chemokine receptors are involved in cell migration and are logical candidates for a role in granuloma formation. In the present study we addressed the role of CC chemokine receptor 2 (CCR2) in M. tuberculosis infection. In previous studies (W. Peters et al., Proc. Natl. Acad. Sci. USA 98:7958-7963, 2001), CCR2(-/-) mice… CONTINUE READING