Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation.

@article{Kbler2015MycobacteriumTD,
  title={Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation.},
  author={Andr{\'e} K{\"u}bler and Brian M Luna and Christer Larsson and Nicole C Ammerman and Bruno Bezerril Andrade and Marlene S. Orandle and Kevin W Bock and Ziyue Xu and Ulas Bagci and Daniel J. Mollura and John Marshall and Jay A Burns and Kathryn Winglee and Bintou Ahmadou Ahidjo and Laurene S. Cheung and Mariah H. Klunk and Sanjay K Jain and Nathella P Kumar and Subash Babu and Alan Sher and Jon S Friedland and Paul T Elkington and William R Bishai},
  journal={The Journal of pathology},
  year={2015},
  volume={235 3},
  pages={431-44}
}
Active tuberculosis (TB) often presents with advanced pulmonary disease, including irreversible lung damage and cavities. Cavitary pathology contributes to antibiotic failure, transmission, morbidity and mortality. Matrix metalloproteinases (MMPs), in particular MMP-1, are implicated in TB pathogenesis. We explored the mechanisms relating MMP/TIMP imbalance to cavity formation in a modified rabbit model of cavitary TB. Our model resulted in consistent progression of consolidation to human-like… CONTINUE READING
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