Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid

  title={Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid},
  author={Argyrides Argyrou and M. Vetting and B. Aladegbami and J. Blanchard},
  journal={Nature Structural &Molecular Biology},
  • Argyrides Argyrou, M. Vetting, +1 author J. Blanchard
  • Published 2006
  • Chemistry, Medicine
  • Nature Structural &Molecular Biology
  • Isoniazid is a key drug used in the treatment of tuberculosis. Isoniazid is a pro-drug, which, after activation by the katG-encoded catalase peroxidase, reacts nonenzymatically with NAD+ and NADP+ to generate several isonicotinoyl adducts of these pyridine nucleotides. One of these, the acyclic 4S isomer of isoniazid-NAD, targets the inhA-encoded enoyl-ACP reductase, an enzyme essential for mycolic acid biosynthesis in Mycobacterium tuberculosis. Here we show that the acyclic 4R isomer of… CONTINUE READING
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