Mycobacterium tuberculosis components stimulate production of the antimicrobial peptide hepcidin.

Abstract

We investigated the in vitro production of the antimicrobial peptide hepcidin by cells of the innate immune system that harbor Mycobacterium tuberculosis. Stimulation of mouse lung macrophages with M. tuberculosis or IFN-γ + M. tuberculosis induced hepcidin mRNA. In human alveolar A549 epithelial cells, lipoglycans of M. tuberculosis, in particular mannose… (More)
DOI: 10.1016/j.tube.2011.03.003

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