Mycobacterium tuberculosis arabinomannan-protein conjugates protect against tuberculosis.

@article{Hamasur2003MycobacteriumTA,
  title={Mycobacterium tuberculosis arabinomannan-protein conjugates protect against tuberculosis.},
  author={Beston Hamasur and Melles Haile and Andrzej Pawlowski and Ulf Joachim Schroeder and Ann Williams and G. Richard Hatch and Graham Hall and Philip Marsh and Gunilla K{\"a}llenius and Stefan B. Svenson},
  journal={Vaccine},
  year={2003},
  volume={21 25-26},
  pages={
          4081-93
        }
}
Lipoarabinomannan (LAM) is a major structural surface component of mycobacteria. Arabinomannan (AM) oligosaccharides derived from LAM of Mycobacterium tuberculosis H37Rv were isolated and covalently conjugated to tetanus toxoid (TT) or to short-term culture filtrate proteins (antigen 85B (Ag85B) or a 75kDa protein) from M. tuberculosis strain Harlingen. The different AM oligosaccharide (AMOs)-protein conjugate vaccine candidates proved to be highly immunogenic, inducing boosterable IgG… CONTINUE READING
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