Mycobacterium tuberculosis and the environment within the phagosome.

  title={Mycobacterium tuberculosis and the environment within the phagosome.},
  author={Kyle H Rohde and Robin M Yates and Georgiana E. Purdy and David G Russell},
  journal={Immunological reviews},
Once across the barrier of the epithelium, macrophages constitute the primary defense against microbial invasion. For most microbes, the acidic, hydrolytically competent environment of the phagolysosome is sufficient to kill them. Despite our understanding of the trafficking events that regulate phagosome maturation, our appreciation of the lumenal environment within the phagosome is only now becoming elucidated through real-time functional assays. The assays quantify pH change, phagosome… CONTINUE READING
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