Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis

@article{Lucarelli2010MycobacteriumTP,
  title={Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis},
  author={Anna Paola Lucarelli and Silvia Buroni and Maria Rosalia Pasca and Menico Rizzi and Andrea Cavagnino and Giovanna Valentini and Giovanna Riccardi and Laurent Roberto Chiarelli},
  journal={PLoS ONE},
  year={2010},
  volume={5}
}
  • Anna Paola Lucarelli, Silvia Buroni, +5 authors Laurent Roberto Chiarelli
  • Published 2010
  • Medicine, Biology
  • PLoS ONE
  • The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant (MDR-TB) and extensively drug-resistant strains (XDR-TB) is a severe public health problem. Currently, there is an urgent need for new drugs for tuberculosis treatment, with novel mechanisms of action and, moreover, the necessity to identify new drug targets. Mycobacterial phosphoribosylpyrophosphate synthetase (MtbPRPPase) is a crucial enzyme involved in the biosynthesis of decaprenylphosphoryl-arabinose, an… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 18 CITATIONS

    Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase.

    VIEW 2 EXCERPTS
    CITES BACKGROUND

    Nucleotide Metabolism and DNA Replication.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 44 REFERENCES