Mycobacterium tuberculosis PhoP recognizes two adjacent direct-repeat sequences to form head-to-head dimers.

@article{Gupta2009MycobacteriumTP,
  title={Mycobacterium tuberculosis PhoP recognizes two adjacent direct-repeat sequences to form head-to-head dimers.},
  author={Sankalp Gupta and Anuj Pathak and Akesh Sinha and Dibyendu Sarkar},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 24},
  pages={
          7466-76
        }
}
Mycobacterium tuberculosis PhoP of the PhoP-PhoR two-component signaling system orchestrates a complex transcription program and is essential for the growth and virulence of the tubercle bacillus. PhoP comprises a phosphorylation domain at the amino-terminal half and a DNA-binding domain in the carboxy-terminal half of the protein. We show here that the protein recognizes a 23-bp sequence of the phoP upstream region comprising two adjacent direct repeat motifs believed to promote transcription… CONTINUE READING

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