Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice

@inproceedings{Reece2018MycobacteriumT,
  title={
Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice},
  author={Stephen Reece and Alexis Vogelzang and Julia Tornack and Wolfgang M Bauer and Ulrike Zedler and Sandra Schommer-Leitner and Georg Stingl and Fritz Georg Melchers and Stefan H E Kaufmann},
  booktitle={The Journal of infectious diseases},
  year={2018}
}
Persistence of Mycobacterium tuberculosis within human bone marrow stem cells has been identified as a potential bacterial niche during latent tuberculosis. Using a murine model of tuberculosis, we show here that bone marrow stem and progenitor cells containing M. tuberculosis propagated tuberculosis when transferred to naive mice, given that both transferred cells and recipient mice were unable to express inducible nitric oxide synthase, which mediates killing of intracellular bacteria via… CONTINUE READING
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