Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes

@inproceedings{Rockwood2017MycobacteriumTI,
  title={Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes},
  author={Neesha Rockwood and Diego Luiz Costa and Eduardo P Amaral and Elsa Du Bruyn and Andr{\'e} Kubler and Leonardo Gil-Santana and Kiyoshi F. Fukutani and Charles A Scanga and JoAnne L. Flynn and Sharon H. Jackson and Katalin Andrea Wilkinson and William R Bishai and Alan Sher and Robert J Wilkinson and Bruno Bezerril Andrade},
  booktitle={Front. Immunol.},
  year={2017}
}
The antioxidant enzyme heme oxygenase-1 (HO-1) is implicated in the pathogenesis of tuberculosis (TB) and has been proposed as a biomarker of active disease. Nevertheless, the mechanisms by which Mycobacterium tuberculosis (Mtb) induces HO-1 as well as how its expression is affected by HIV-1 coinfection and successful antitubercular therapy (ATT) are poorly understood. We found that HO-1 expression is markedly increased in rabbits, mice, and non-human primates during experimental Mtb infection… CONTINUE READING
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