Mycobacterium tuberculosis H37Rv ESAT-6-CFP-10 complex formation confers thermodynamic and biochemical stability.

@article{Meher2006MycobacteriumTH,
  title={Mycobacterium tuberculosis H37Rv ESAT-6-CFP-10 complex formation confers thermodynamic and biochemical stability.},
  author={Akshaya K Meher and Naresh Chandra Bal and Kandala V R Chary and Ashish Arora},
  journal={The FEBS journal},
  year={2006},
  volume={273 7},
  pages={1445-62}
}
The 6-kDa early secretory antigenic target (ESAT-6) and culture filtrate protein-10 (CFP-10), expressed from the region of deletion-1 (RD1) of Mycobacterium tuberculosis H37Rv, are known to play a key role in virulence. In this study, we explored the thermodynamic and biochemical changes associated with the formation of the 1 : 1 heterodimeric complex between ESAT-6 and CFP-10. Using isothermal titration calorimetry (ITC), we precisely determined the association constant and free energy change… CONTINUE READING

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