Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.

Abstract

The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis. Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis (Msm) in macrophages. Mtb Eis was shown to suppress host immune defenses by negatively modulating autophagy, inflammation, and cell death through JNK-dependent… (More)
DOI: 10.1073/pnas.1120251109

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@article{Kim2012MycobacteriumTE, title={Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7.}, author={Kyoung Hoon Kim and Doo Ri An and Jinsu Song and Ji Young Yoon and Hyoun Sook Kim and Hye Jin Yoon and Ha Na Im and Jieun Kim and Do Jin Kim and Sang Jae Lee and Ki-Hye Kim and Hye-Mi Lee and Hie-Joon Kim and Eun Kyeong Jo and Jae Young Lee and Se Won Suh}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2012}, volume={109 20}, pages={7729-34} }