Mycobacterium tuberculosis ESAT6 induces IFN-β gene expression in Macrophages via TLRs-mediated signaling.

@article{Jang2017MycobacteriumTE,
  title={Mycobacterium tuberculosis ESAT6 induces IFN-β gene expression in Macrophages via TLRs-mediated signaling.},
  author={Ah-Ra Jang and Ji-Eun Choi and Sung Jae Shin and Jong-Hwan Park},
  journal={Cytokine},
  year={2017},
  volume={104},
  pages={
          104-109
        }
}
Mycobacterium tuberculosis is a highly virulent bacterium that causes tuberculosis. It infects about one third of the world's population. Type I interferons (IFNs) play a detrimental role in host defense against M. tuberculosis infection. Proteins secreted by M. tuberculosis through ESX-1 secretion system contribute to type I IFNs production. However, the precise mechanism by which 6-kDa early secretory antigen target (ESAT6), one of ESX-1-mediated secretory proteins, induces type I IFNs… CONTINUE READING

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