Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates.

@article{Manca1999MycobacteriumTC,
  title={Mycobacterium tuberculosis CDC1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates.},
  author={Claudia Manca and Liana Georgieva Tsenova and Clifton E Barry and Amy Bergtold and Sherry Freeman and Patrick A. J. Haslett and James M. Musser and Victoria H. Freedman and Gilla Kaplan},
  journal={Journal of immunology},
  year={1999},
  volume={162 11},
  pages={6740-6}
}
Mycobacterium tuberculosis CDC1551, a clinical isolate reported to be hypervirulent and to grow faster than other isolates, was compared with two other clinical isolates (HN60 and HN878) and two laboratory strains (H37Rv and Erdman). The initial (1-14 days) growth of CDC1551, HN60, HN878, and H37Rv was similar in the lungs of aerosol-infected mice, but growth of Erdman was slower. Thereafter, the growth rate of CDC1551 decreased relative to the other strains which continued to grow at… CONTINUE READING

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