Mycobacterium tuberculosis 38-kDa lipoprotein is apoptogenic for human monocyte-derived macrophages.

@article{Snchez2009MycobacteriumT3,
  title={Mycobacterium tuberculosis 38-kDa lipoprotein is apoptogenic for human monocyte-derived macrophages.},
  author={Alvar S{\'a}nchez and Patricia Rodr{\'i}guez Espinosa and M. A. Esparza and Migdalisel Col{\`o}n and Giuliano Bernal and Ra{\'u}l Mancilla},
  journal={Scandinavian journal of immunology},
  year={2009},
  volume={69 1},
  pages={20-8}
}
Mycobacterium tuberculosis is the main aetiologic agent of tuberculosis, a disease of great concern in less-developed regions. Apoptosis is a conspicuous event in macrophages infected in vitro with mycobacteria, a phenomenon also observed in vivo in granulomas of patients with tuberculosis. To determine its significance, it is important to define the mycobacterial moieties involved and how they cause apoptosis. Here we show that the 38-kDa lipoprotein induces macrophage caspase-dependent… CONTINUE READING