Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.

@article{Elkington2005MycobacteriumTB,
  title={Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.},
  author={Paul T Elkington and Robert K. Nuttall and Joseph J Boyle and Cecilia O'kane and Donna E. Horncastle and Dylan Ross Edwards and Jon S Friedland},
  journal={American journal of respiratory and critical care medicine},
  year={2005},
  volume={172 12},
  pages={
          1596-604
        }
}
RATIONALE Pulmonary cavitation is fundamental to the global success of Mycobacterium tuberculosis. However, the mechanisms of this lung destruction are poorly understood. The biochemistry of lung matrix predicts matrix metalloproteinase (MMP) involvement in immunopathology. METHODS We investigated gene expression of all MMPs, proteins with a disintegrin and metalloproteinase domain, and tissue inhibitors of metalloproteinases in M. tuberculosis-infected human macrophages by real-time… CONTINUE READING

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