Mycobacterium smegmatis phosphoinositols-glyceroarabinomannans. Structure and localization of alkali-labile and alkali-stable phosphoinositides.

@article{Gilleron1997MycobacteriumSP,
  title={Mycobacterium smegmatis phosphoinositols-glyceroarabinomannans. Structure and localization of alkali-labile and alkali-stable phosphoinositides.},
  author={Martine Gilleron and Nourredine Himoudi and Otmar Adam and Patricia Constant and A Venisse and Michel Riviere and Germain Puzo},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 1},
  pages={117-24}
}
Lipoarabinomannans from fast growing Mycobacterium sp., namely AraLAMs, stimulate the early events of macrophage activation. The immunological activities of all of these AraLAMs drastically decrease with the loss of the mild alkali groups, which were believed to be restricted to the fatty acid residues from the phosphatidyl-myo-inositol anchor. This report reveals the presence and the structure of mild alkali-labile phosphoinositide units linked via the phosphate to the C-5 of the beta-D-Araf… CONTINUE READING