Mycobacterium smegmatis Erm(38) is a reluctant dimethyltransferase.

  title={Mycobacterium smegmatis Erm(38) is a reluctant dimethyltransferase.},
  author={Christian Toft Madsen and Lene Jakobsen and S. Douthwaite},
  journal={Antimicrobial agents and chemotherapy},
  volume={49 9},
The waxy cell walls of mycobacteria provide intrinsic tolerance to a broad range of antibiotics, and this effect is augmented by specific resistance determinants. The inducible determinant erm(38) in the nontuberculous species Mycobacterium smegmatis confers high resistance to lincosamides and some macrolides, without increasing resistance to streptogramin B antibiotics. This is an uncharacteristic resistance pattern falling between the type I and type II macrolide, lincosamide, and… CONTINUE READING