Mycobacterium leprae inhibits dendritic cell activation and maturation.

  title={Mycobacterium leprae inhibits dendritic cell activation and maturation.},
  author={Rose Ann Murray and Mahveen Ruby Siddiqui and Megan Mendillo and James L. Krahenbuhl and Gilla Kaplan},
  journal={Journal of immunology},
  volume={178 1},
Leprosy presents with a clinical spectrum of skin lesions that span from strong Th1-mediated cellular immunity and control of bacillary growth at one pole to poor Ag-specific T cell immunity with extensive bacillary load and Th2 cytokine-expressing lesions at the other. To understand how the immune response to Mycobacterium leprae is regulated, human dendritic cells (DC), potent inducers of adaptive immune responses, exposed to M. leprae, Mycobacterium tuberculosis (Mtb), and Mycobacterium… CONTINUE READING


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