Mycobacterium bovis bacillus Calmette-Guérin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism.

@article{Cheadle2003MycobacteriumBB,
  title={Mycobacterium bovis bacillus Calmette-Gu{\'e}rin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism.},
  author={Eleanor J. Cheadle and Peter John Selby and Andrew M. Jackson},
  journal={Immunology},
  year={2003},
  volume={108 1},
  pages={79-88}
}
Mycobacteria are potent adjuvants, can survive intracellularly and have been safely used for many years as vaccines against tuberculosis and leprosy. They are thus important potential vectors for recombinant vaccines. Many of their adjuvant properties are mediated following phagocytosis by dendritic cells (DC), which are in turn critical for priming naïve T cells. Although the maturation of DC in response to mycobacteria, such as Mycobacterium bovis bacillus Calmette-Guérin (BCG), is well… CONTINUE READING