Mycobacterium bovis BCG killed by extended freeze-drying reduces airway hyperresponsiveness in 2 animal models.

@article{Lagranderie2008MycobacteriumBB,
  title={Mycobacterium bovis BCG killed by extended freeze-drying reduces airway hyperresponsiveness in 2 animal models.},
  author={Micheline Lagranderie and Mohammad A. Abolhassani and Jeroen Alfons Vanoirbeek and J. -M. Lefort and M. A. Nahori and Jose-Roberto Lapa e Silva and Michel Ren{\'e} Huerre and Boris B. Vargaftig and Gilles Marchal},
  journal={The Journal of allergy and clinical immunology},
  year={2008},
  volume={121 2},
  pages={471-8}
}
BACKGROUND Live BCG administered intranasally to mice inhibits the development of ovalbumin (OVA)-induced eosinophilia and airway hyperresponsiveness (AHR). It is unacceptable to treat human subjects intranasally with live BCG. OBJECTIVE We investigated whether BCG killed by extended freeze-drying (EFD) and subcutaneously injected has a protective effect in murine and guinea pig models of allergic airway inflammation. METHODS Mice were OVA sensitized (days 0 and 7), treated subcutaneously… CONTINUE READING

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